Professor Anne Petitjean, Department of Chemistry, Queen's University
Guanine quadruplexes: a tale of unraveling discoveries in nucleic acid targeting
Friday, October 21, 2016
Room 208 Tory Building
The past 15 years have seen a revolution in nucleic acid structure and function; guanine quadruplexes, an alternate family of structures of nucleic acids which differs from the traditionally recognized double-helix, have revealed themselves from curiosities suspected to occur in obscure fragments of DNA, to a massively present motif in DNA, RNA and DNA-RNA hybrids in a variety of contexts (e.g., mammals, insects, plants,viruses). Evidence is increasingly suggesting that guanine quadruplexes are heavily involved in the regulation of essential processes that play important roles in conditions as varied as cancers, infectious diseases and neurological disorders.
This presentation will relate the incredible discoveries that are leading to the realization of the guanine quadruplex motif prominence, together with the tale of our group’s happy accidental incursions in the field.